Psychiatric genetics; what's new in 2015?

Corvin A, O'Donovan MC

Lancet Psychiatry, 2016

A useful guide to the state of the field in 2015 showing that landmark discoveries in schizophrenia are beginning to be replicated in other psychiatric disorders.

 

 

 

 

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways.

Network and Pathway Analysis Subgroup of Psychiatric Genomics Consortium

Nature Neuroscience, 2015

In this large collaborative study we show that common risk variants aggregate in biological pathways and that these pathways are shared between schizophrenia, bipolar disorder and depression.

 

 

 

 

 

Biological insights from 108 schizophrenia-associated loci

Schizophrenia Working Group of the Psychiatric Genomics Consortium

Nature, 2014

In the largest reported genome-wide association study (GWAS) of schizophrenia we identify associations spanning 108 loci:  83 of these were new findings.

 

 

 

 

 

De novo mutations in schizophrenia implicate chromatin remodelling and support genetic overlap with ASD and ID

McCarthy et al.

Molecular Psychiatry, 2014

In one of the first published schizophrenia whole exome studies we report an excess of mutations involving genes that regulate transcription including CHD8, MECP2 and HUWE1.

 

 

 

 

 

An inherited duplication at the gene P21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis

Morris DW et al.

Human Molecular Genetics, 2014

We find evidence that a rare duplication at this gene, likely inherited from a single founder, increases risk of schizophrenia and bipolar disorder in Ireland and other populations.

 

 

 

 

 

Excess of rare novel loss-of-function variants in synaptic genes in schizophrenia and autism spectrum disorders

Kenny EM, et al.

Molecular Psychiatry, 2014

In our first major sequencing project loss of function variants were over-represented in Neurexin and Neuroligin Interacting Protein genes: neatly mirroring the finding from our earlier pathway analysis of SNP data.

 

 

 

 

 

Genome-wide association study implicates HLA-C*01:02 as a risk factor at the major histocompatibility complex locus in schizophrenia

Irish Schizophrenia Genomics Consortium & WTCCC2

Biological Psychiatry, 2012

In a GWAS study of our cohort we provided further evidence for the role of MHC class I molecules in schizophrenia etiology.

 

 

 

 

 

Molecular pathways involved in neuronal cell adhesion and membrane scoffolding contribute to schizophrenia and bipolar disorder susceptibility

O'Dushlaine C, et al.

Molecular Psychiatry 2011

 

 

 

 

 

Common polygenic variation contributes to risk in schizophrenia and bipolar disorder

International Schizophrenia Consortium

Nature, 2009

 

 

 

 

 

Rare chromosomal deletions and duplications increase risk of schizophrenia

International Schizophrenia Consortium

Nature, 2008