Research
Imaging
Genetic influences on schizophrenia and subcortical volumes: large-scale proof of concept
Franke B, et al.
Nature Neuroscience, 2016
A useful guide to the state of the field in 2015 showing that landmark discoveries in schizophrenia are beginning to be replicated in other psychiatric disorders.
Common genetic variants influence human subcortical brain structures
Hibar DP, et al.
Nature, 2015
In this large collaborative study we show that common risk variants aggregate in biological pathways and that these pathways are shared between schizophrenia, bipolar disorder and depression.
Effects of MIR137 on fronto-amygdala functional connectivity
Mothersill O, et al.
Neuroimage, 2014
In the largest reported genome-wide association study (GWAS) of schizophrenia we identify associations spanning 108 loci: 83 of these were new findings.
Effects of a novel schizophrenia risk variant at CNNM2 on brain structure and attributional style
Rose EJ, et al.
British Journal of Psychiatry, 2014
In one of the first published schizophrenia whole exome studies we report an excess of mutations involving genes that regulate transcription including CHD8, MECP2 and HUWE1.
Psychosis susceptibility gene ZNF804A and cognitive performance in schizophrenia
Walters JT, et al.
Archives of General Psychiatry, 2010
We find evidence that a rare duplication at this gene, likely inherited from a single founder, increases risk of schizophrenia and bipolar disorder in Ireland and other populations.
Computerized working-memory focused cognitive remediation therapy for psychosis: a preliminary study
Hargreaves A, et al.
Nature Neuroscience, 2015
In this large collaborative study we show that common risk variants aggregate in biological pathways and that these pathways are shared between schizophrenia, bipolar disorder and depression.
Variability in working memory performance explained by epistasis vs polygenic scores in the ZNF804A pathway
Nicodemus KK, et al.
JAMA Psychiatry, 2014
In the largest reported genome-wide association study (GWAS) of schizophrenia we identify associations spanning 108 loci: 83 of these were new findings.
Effects of ZNF804A on auditory P300 response in schizophrenia
O'Donoghue T, et al.
Translational Psychiatry, 2014
In one of the first published schizophrenia whole exome studies we report an excess of mutations involving genes that regulate transcription including CHD8, MECP2 and HUWE1.
Mood congruent psychotic symptoms and specific cognitive deficits in carriers of the schizophrenia risk variant at MIR-137
Cummings E, et al.
Neuroscience Letters, 2013
We find evidence that a rare duplication at this gene, likely inherited from a single founder, increases risk of schizophrenia and bipolar disorder in Ireland and other populations.
ZNF804A and social cognition in patients with schizophrenia and healthy controls
Hargreaves A, et al.
Molecular Psychiatry, 2012
In our first major sequencing project loss of function variants were over-represented in Neurexin and Neuroligin Interacting Protein genes: neatly mirroring the finding from our earlier pathway analysis of SNP data.